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Mg/ml shows the amount of nicotine per milligram (mg) per millilitre (ml) of liquid, and a percentage figure shows the amount of nicotine as a percentage per total

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The majority of state laws about e-cigarettes have prohibited sales to minors, consistent with the very high level of public support for such restrictions

Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

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